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Human breast epithelial stem cells and their regulation.
Kalirai H, Clarke RB
J Pathol. 2006;208( 1):7-16.
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Abstract
This review summarizes the current evidence for the existence of human breast stem cells and the pathways involved in their regulation, and discusses how the disruption of these pathways may result in the generation of a population of cells with the capacity for unlimited self-renewal. Relevant data from mouse model systems are also discussed where appropriate. By understanding the molecular pathways that regulate self-renewal of normal mammary stem cells, it may be possible to target the activation of these pathways in breast tumours. Copyright 2005 Pathological Society of Great Britain and Ireland.
Keyword(s)
Adult; Female; Humans; Models, Biological; Research Support, Non-U.S. Gov't; cytology: Breast; cytology: Mammary Glands, Human; genetics: Breast Neoplasms; genetics: Estrogen Receptor alpha; genetics: Gene Expression Regulation, Neoplastic; genetics: Genes, Neoplasm; genetics: Signal Transduction; physiology: Cell Division; physiology: Epithelial Cells; physiology: Stem Cells
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- Journal Article