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DOI: 10.1038/sj.bjc.6603515

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DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents

O'Connor JP B, Jackson A-, Parker GJM, Jayson G-

British Journal Of Cancer. 2007;96:189-195.

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Full-text held externally

DOI: 10.1038/sj.bjc.6603515

Abstract

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is now frequently used in early clinical trial assessment of antiangiogenic and vascular disrupting compounds. Evidence of drug efficacy and dose-dependent response has been demonstrated with some angiogenesis inhibitors. This review highlights the critical issues that influence T-1-weighted DCE-MRI data acquisition and analysis, identifies important areas for future development and reviews the clinical trial findings to date.

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Type of resource:

text

Content type:

Journal article

Publication type:

Review article

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University researcher(s):

Parker, Geoffrey

Academic department(s):

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Manchester eScholar ID:

uk-ac-man-scw:1d27617

Created:

2nd September, 2009, 09:40:45

Last modified:

25th December, 2014, 21:03:21