What levels of precision are achievable for quantification of perfusion and capillary permeability surface area product using ASL?

Access to files

Full-text and supplementary files are not available from Manchester eScholar. Full-text is available externally using the following links:

Abstract

We examine the use of arterial spin labeling (ASL) in normalbrains of rats and humans to measure perfusion (F) and capillarypermeability surface area product (PS) using a previouslydescribed two-compartment model. We investigate the experimentallimits on F and PS quantification using simulations andexperimental verification in rat brain at 9.4T. A sensitivity analysison the two-compartment model is presented to estimateoptimal experimental inversion times (TIs) for F and PS quantificationand indicate how sensitive the model would be tochanges in F and PS. We present the expected error on flowsensitivealternating inversion recovery (FAIR)-based F and PSmeasurements and quantify the precision with which theseparameters could be estimated at various signal-to-noise ratios(SNRs). Perfusion was measured in four rat brains using FAIRASL, and we conclude that perfusion could be quantified withan acceptable level of precision using this technique. However,we found that to measure PS with even a 100% coefficient ofvariation (CV) would require an SNR increase of approximately2 orders of magnitude over our acquired data. We conclude thatwith current MR capabilities and with the experimental approachused in this study, acceptable levels of precision in themeasurement of PS are not possible.

Bibliographic metadata

Institutional metadata

Record metadata