Related resources
Full-text held externally
- DOI: 10.1002/mrm.21815
Search for item elsewhere
University researcher(s)
Academic department(s)
Comparison of normal tissue R1 and R2* modulation by oxygen and carbogen
O'Connor, JP B, Naish, J, Jackson, A-, Waterton, JC, Watson, YY, Cheung, SW, Buckley, DL, McGrath, DM, Buonaccorsi, G, Mills, S, Roberts, C, Jayson, G-, Parker, GJM
Magnetic Resonance In Medicine. 2009;61:75-83.
Access to files
Full-text and supplementary files are not available from Manchester eScholar. Full-text is available externally using the following links:
Full-text held externally
- DOI: 10.1002/mrm.21815
Abstract
Magnetic resonance imaging has shown promise for evaluatingtissue oxygenation. In this study differences in the tissue longitudinalrelaxation rate (R1) and effective transverse relaxationrate (R*2), induced by inhalation of pure oxygen and carbogen,were evaluated in 10 healthy subjects. Significant reductions inR1 were demonstrated following both oxygen and carbogeninhalation in the spleen (both P < 0.001), liver (P 0.002 air vs.oxygen; P 0.001 air vs. carbogen), skeletal muscle (both P <0.001), and renal cortex (P 0.005 air vs. oxygen; P 0.008 airvs. carbogen). No significant change in R*2 occurred followingpure oxygen in any organ. However, a significant increase in R*2was observed in the spleen (P < 0.001), liver (P 0.001), skeletalmuscle (P 0.026), and renal cortex (P 0.001) followingcarbogen inhalation, an opposite effect to that observed inmany studies of tumor pathophysiology. Changes in R1 and R*2were independent of the gas administration order in the spleenand skeletal muscle. These findings suggest that the R1 and R*2responses to hyperoxic gases are independent biomarkers ofoxygen physiology. Magn Reson Med 61:75–83, 2009. © 2008Wiley-Liss, Inc.Key words: biomarker; carbogen; effective transverse relaxationrate; longitudinal relaxation rate; oxygen; physiology