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Comparison of normal tissue R1 and R2* modulation by oxygen and carbogen

O'Connor, JP B, Naish, J, Jackson, A-, Waterton, JC, Watson, YY, Cheung, SW, Buckley, DL, McGrath, DM, Buonaccorsi, G, Mills, S, Roberts, C, Jayson, G-, Parker, GJM

Magnetic Resonance In Medicine. 2009;61:75-83.

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Abstract

Magnetic resonance imaging has shown promise for evaluatingtissue oxygenation. In this study differences in the tissue longitudinalrelaxation rate (R1) and effective transverse relaxationrate (R*2), induced by inhalation of pure oxygen and carbogen,were evaluated in 10 healthy subjects. Significant reductions inR1 were demonstrated following both oxygen and carbogeninhalation in the spleen (both P < 0.001), liver (P 0.002 air vs.oxygen; P 0.001 air vs. carbogen), skeletal muscle (both P <0.001), and renal cortex (P 0.005 air vs. oxygen; P 0.008 airvs. carbogen). No significant change in R*2 occurred followingpure oxygen in any organ. However, a significant increase in R*2was observed in the spleen (P < 0.001), liver (P 0.001), skeletalmuscle (P 0.026), and renal cortex (P 0.001) followingcarbogen inhalation, an opposite effect to that observed inmany studies of tumor pathophysiology. Changes in R1 and R*2were independent of the gas administration order in the spleenand skeletal muscle. These findings suggest that the R1 and R*2responses to hyperoxic gases are independent biomarkers ofoxygen physiology. Magn Reson Med 61:75&#150;83, 2009. &#169; 2008Wiley-Liss, Inc.Key words: biomarker; carbogen; effective transverse relaxationrate; longitudinal relaxation rate; oxygen; physiology

Bibliographic metadata

Type of resource:
Content type:
Publication type:
Publication form:
Published date:
Volume:
61
Start page:
75
End page:
83
Pagination:
75-83
Digital Object Identifier:
10.1002/mrm.21815
Access state:
Active

Institutional metadata

University researcher(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:1d28355
Created:
2nd September, 2009, 10:04:36
Last modified:
25th December, 2014, 20:59:03

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