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Modeling of contrast agent kinetics in the lung using T1-weighted dynamic contrast-enhanced MRI
Naish J, Kershaw L, Buckley DL, Jackson A-, Waterton JC, Parker GJM
Magnetic Resonance In Medicine. 2009;16:1507-1514.
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Abstract
Assessment of perfusion and capillary permeability is importantin both malignant and nonmalignant lung disease. Kinetic modelingof T1-weighted dynamic contrast-enhanced MRI (DCEMRI)data may provide such an assessment. This study establishesthe feasibility and interrelationship of kinetic modelingapproaches designed to estimate microvascular properties inmalignant and nonmalignant tissues of the lung. DCE-MRI datawere acquired using a low molecular weight contrast agent with4-sec temporal resolution in lung cancer patients. A model-freeparameterization and three kinetic models of increasing complexity,each related to the classical Kety model, were applied.Comparison of an extended Kety model and the adiabatic approximationto the tissue homogeneity (AATH) model usingAkaike’s Information Criterion suggested that in most cases thebest description of the lung tumor data is obtained using theAATH model. In the normal lung parenchyma the temporal resolutionwas insufficient to separate effects of flow and contrastagent leakage and in this case the extended Kety model yieldedthe best fit to the data. Magn Reson Med 61:1507–1514, 2009.© 2009 Wiley-Liss, Inc.Key words: lung; perfusion; capillary permeability; cancer