Related resources
Search for item elsewhere
University researcher(s)
Academic department(s)
Metabolic and febrile responses to typhoid vaccine in humans: effect of beta-adrenergic blockade.
Cooper A, Horan M, Little R, Rothwell NJ
J Appl Physiol. 1992;72( 6):2322-8.
Access to files
Full-text and supplementary files are not available from Manchester eScholar. Use our list of Related resources to find this item elsewhere. Alternatively, request a copy from the Library's Document supply service.
Abstract
Fever and activation of acute phase responses were induced in human volunteers by intramuscular injection of typhoid vaccine. Vaccine injection caused a rapid (within 1 h) and sustained rise in metabolic rate (peak response 16%, 6-8 h), followed by later increases in white blood cell count (3-4 h), skin temperature (4-5 h), oral temperature (5-6 h), heart rate (6-8 h), and plasma cortisol (5-8 h). A peak fever [1.2 +/- 0.2 degree C (SE) rise] was recorded 12 h after vaccine injection. The involvement of the sympathetic nervous system in the development of these responses was investigated by the oral administration of propranolol before (80 mg) and 3 h after (40 mg) vaccine injection. Propranolol prevented the increases in metabolic rate, heart rate, and skin temperature but did not inhibit the rise in oral temperature or white cell count after vaccine administration. These data indicate that the sympathetic nervous system is responsible for the rise in energy expenditure associated with fever in humans. However, the rise in body temperature can develop in the absence of this increase in metabolic rate possibly by changes in heat loss.
Keyword(s)
Adolescent; Adult; Female; Human; Male; Support, Non-U.S. Gov't; adverse effects: Typhoid-Paratyphoid Vaccines; drug effects: Heart Rate; drug effects: Metabolism; drug effects: Skin Temperature; etiology: Acute-Phase Reaction; etiology: Fever; pharmacology: Propranolol; physiology: Receptors, Adrenergic, beta