Related resources
Search for item elsewhere
University researcher(s)
Academic department(s)
Central activation of thermogenesis and fever by interleukin-1 beta and interleukin-1 alpha involves different mechanisms.
Busbridge N, Dascombe M, Tilders F, van Oers J, Linton E, Rothwell NJ
Biochem Biophys Res Commun. 1989;162( 2):591-6.
Access to files
Full-text and supplementary files are not available from Manchester eScholar. Use our list of Related resources to find this item elsewhere. Alternatively, request a copy from the Library's Document supply service.
Abstract
Interleukin-1 exists in two forms (alpha and beta) which are assumed to act on the same receptor. Both forms of the molecule stimulated fever and thermogenesis in the rat when injected into the brain, but interleukin-1 beta was more effective, and combined injection of alpha and beta elicited additive responses. The actions of interleukin-1 beta were inhibited by pretreatment of the animals with either a receptor antagonist or monoclonal antibody to corticotrophin releasing factor. The effects of interleukin-1 alpha were unaltered by these treatments. The results indicate that brain corticotrophin releasing factor mediates thermogenesis and fever induced by interleukin-1 beta but not by interleukin-1 alpha.
Keyword(s)
Animals; Antibodies, Monoclonal; Body Temperature; Body Temperature Regulation; Brain; Comparative Study; Immunization, Passive; Male; Oxygen Consumption; Rats; Rats, Inbred Strains; Support, Non-U.S. Gov't; administration & dosage: Interleukin-1; antagonists & inhibitors: Corticotropin-Releasing Hormone