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Detection of the interleukin 18 family in rat brain by RT-PCR.
Wheeler R, Culhane A, Hall M, Pickering-Brown S, Rothwell NJ, Luheshi G
Brain Res Mol Brain Res. 2000;77( 2):290-3.
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Abstract
Interleukin 18, an inflammatory cytokine, mediates its effects by interaction with its receptor complex, consisting of the IL-18 receptor (IL-18R) and receptor accessory protein (AcPL). A functional inhibitor of IL-18, the IL-18 binding protein (IL-18BP), has been identified recently. This study reports the detection of IL-18, IL-18R, AcPL and IL-18BP mRNA expression in the brain of normal adult rats using RT-PCR.
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Animals; Male; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Support, Non-U.S. Gov't; analysis: RNA, Messenger; genetics: Glycoproteins; genetics: Interleukin-18; genetics: Receptors, Interleukin; genetics: Receptors, Interleukin-1; metabolism: Brain