Corticotrophin-releasing factor antagonist inhibits neuronal damage induced by focal cerebral ischaemia or activation of NMDA receptors in the rat brain.

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Abstract

This study investigated the involvement of corticotrophin-releasing factor (CRF) in acute neuronal damage induced by focal cerebral ischaemia or pharmacological activation of NMDA receptors in the rat brain. Intracerebroventricular injection of a CRF receptor antagonist (alpha-helical CRF9-41), markedly inhibited ischaemic (61%) and excitotoxic (41%) brain damage. Peripheral injection of a glucocorticoid antagonist (RU38486) did not affect ischaemic damage. Ischaemic and excitotoxic damage caused increased hypothalamic concentrations of CRF. These data indicate that CRF mediates ischaemic and excitotoxic neuronal damage in the rat, but that this effect is not dependent on glucocorticoids.

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Animals; Injections, Intraventricular; Male; Rats; Rats, Sprague-Dawley; Support, Non-U.S. Gov't; administration & dosage: Corticotropin-Releasing Hormone; administration & dosage: Mifepristone; administration & dosage: Peptide Fragments; antagonists & inhibitors: Receptors, N-Methyl-D-Aspartate; drug effects: Body Temperature; drug effects: Brain; drug effects: Hypothalamus; drug effects: Neurons; pathology: Ischemic Attack, Transient

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