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Brown adipose tissue activity and oxygen consumption after scald injury in the rat.
Rothwell NJ, Little R, Rose J
Circ Shock. 1991;33( 1):33-6.
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Abstract
Scald injury (30% surface scald) in the rat caused rapid (1-3 h) and transient decreases in oxygen consumption (VO2 20%), colonic temperature (1.1 degree C), and brown adipose tissue (BAT) thermogenic activity (22%). Three days after injury, VO2 was slightly increased in injured rats, and sympathetically mediated heat production (assessed from the inhibitory effect of a beta-adrenergic antagonist on VO2) was significantly greater than than for controls. At this time, BAT activity (in vitro mitochondrial GDP binding) was 35% higher in injured than control rats. Food intake was inhibited for only 24 h in injured animals, but weight gain was suppressed for at least 3 days. The data indicate that sympathetic modification of BAT thermogenesis may contribute to the changes in metabolic rate and body weight gain after scald injury in the rat.
Keyword(s)
Animals; Male; Oxygen Consumption; Rats; Rats, Inbred Strains; Weight Gain; metabolism: Brown Fat; metabolism: Burns; physiology: Body Temperature Regulation; physiopathology: Colon