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Anorexic but not pyrogenic actions of interleukin-1 are modulated by central melanocortin-3/4 receptors in the rat.
Lawrence C, Rothwell NJ
J Neuroendocrinol. 2001;13( 6):490-5.
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Abstract
The cytokine interleukin-1 (IL-1), which mediates many responses to infection and injury, induces anorexia and fever through direct actions in the central nervous system. The melanocortin neuropeptides, such as alpha melanocyte-stimulating hormone (alpha-MSH), reportedly antagonize many actions of IL-1, including fever and anorexia. However, it is unknown whether endogenous melanocortins modulate anorexia induced by IL-1. The objective of the present study was to establish the effect of endogenous melanocortins on IL-1-induced anorexia and fever in the rat. Intracerebroventricular (i.c.v.) injection of IL-1beta caused a significant reduction in food intake and body weight gain, and a rise in core body temperature in conscious rats. Coadministration of the melanocortin-3/4 receptor (MC3/4-R) antagonist, SHU9119, reversed IL-1beta-induced reductions in food intake and body weight, but did not affect the febrile response to IL-1beta. These data suggest IL-1beta may elicit its effects on food intake through the melanocortin system, predominantly via the MC3-R or MC4-R. In contrast, IL-1beta-induced fever does not appear to be mediated or modulated by MC3-R or MC4-R activity.
Keyword(s)
Animals; Injections, Intraventricular; Kinetics; Male; Rats; Rats, Sprague-Dawley; Receptors, Melanocortin; Support, Non-U.S. Gov't; administration & dosage: Appetite Depressants; administration & dosage: Interleukin-1; administration & dosage: MSH; administration & dosage: Pyrogens; administration & dosage: alpha-MSH; agonists: Receptors, Corticotropin; chemically induced: Anorexia; chemically induced: Fever; drug effects: Body Temperature; drug effects: Brain; drug effects: Eating; drug effects: Weight Loss