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Comparative in vivo lung delivery of hydrofluoroalkane-salbutamol formulation via metered-dose inhaler alone, with plastic spacer, or with cardboard tube.

Fowler SJ, Wilson A, Griffiths E, Lipworth B

Chest. 2001;119( 4):1018-20.

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Abstract

STUDY OBJECTIVE: To compare the lung delivery of chlorofluorocarbon-free salbutamol via a pressurized metered-dose inhaler (pMDI) alone, a pMDI with a small-volume plastic spacer, and a pMDI with a cardboard tube. DESIGN: A randomized, single (investigator)-blind, three-way, crossover study. SETTING: The Asthma and Allergy Research Group, Ninewells Hospital, University of Dundee, Dundee, Scotland, UK. PARTICIPANTS: Twelve healthy volunteers aged 16 to 65 years. INTERVENTIONS: The subjects were administered 400 microg of salbutamol via a pMDI alone, via a pMDI plus a small-volume plastic spacer, or via a pMDI plus a cardboard tube. MEASUREMENTS AND RESULTS: Blood samples for plasma salbutamol concentrations were taken at 5 min, 10 min, and 20 min after inhalation, to measure lung bioavailability as a surrogate for relative lung dose. The addition of the plastic spacer resulted in a significantly higher maximal plasma salbutamol concentration (CMAX) and average plasma salbutamol concentration (CAV) than the pMDI used alone. This amounted to a 1.48-fold (32%) difference (95% confidence interval [CI], 1.03 to 2.13) for CMAX and a 1.42-fold (30%) difference (95% CI, 1.01 to 2.00) for CAV. There was no significant difference in the CMAX or CAV comparing the addition of the cardboard tube with the plastic spacer or the pMDI alone. CONCLUSIONS: Using a chlorofluorocarbon-free pMDI with a plastic spacer produced statistically, but not biologically, significant greater lung delivery of salbutamol. If a spacer is required for reasons other than increasing delivered drug dose, then the addition of a readily available cardboard tube will fulfill many of the required functions with no expense to the patient.

Bibliographic metadata

Type of resource:
Content type:
Publication type:
Published date:
Journal title:
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Place of publication:
United States
Volume:
119( 4)
Start page:
1018
End page:
20
Pagination:
1018-20
Access state:
Active

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Record metadata

Manchester eScholar ID:
uk-ac-man-scw:1d29916
Created:
2nd September, 2009, 12:04:01
Last modified:
2nd September, 2009, 12:04:01

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