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Wheeze Phenotypes and Lung Function in Pre-School Children.

Lowe L, Simpson A, Woodcock AA, Morris J, Murray CS, Custovic A

Am J Respir Crit Care Med. 2005;171(3).

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Abstract

Distinct phenotypes can be identified in childhood wheezing illness.Within the context of a birth cohort study, we investigated theassociation between pre-school lung function and phenotypes of wheeze.Based on parentally-reported history of wheeze (interviewer-administeredquestionnaire, age 3 and 5 years), children were classified as neverwheezers, transient early wheezers, late-onset wheezers or persistentwheezers. Lung function (specific airway resistance-sRaw;kiloPascal/second) was assessed at age 3 (n=463) and 5 years (n=690).Persistent wheezers had markedly poorer lung function compared to othergroups. In children who had wheezed by age 3 years, the risk of persistentwheeze increased with increased sRaw (odds ratio, 95% confidenceintervals: 5.2, 1.3-22.0, p=0.02). In a multivariate model, increasingsRaw (5.5, 1.2-25.9, p=0.03) and child's sensitisation (2.8, 1.3-5.8,p=0.008) were significant independent predictors of persistent wheezing.We found no association between lung function at age three and late-onsetwheeze in children who had not wheezed previously (0.6, 0.07-5.3, p=0.64).In conclusion, poor lung function at age 3 years predicted the subsequentpersistence of symptoms in children who had wheezed within the first 3years, but was not associated with the onset of wheeze after age 3 yearsin children who had not wheezed previously.

Bibliographic metadata

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Place of publication:
United States
Volume:
171(3)
Digital Object Identifier:
10.1164/rccm.200406-695OC
Access state:
Active

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:1d9085
Created:
29th August, 2009, 14:54:33
Last modified by:
Murray, Clare
Last modified:
29th September, 2015, 13:31:01

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