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Reported versus confirmed wheeze and lung function in early life.
Lowe, L, Murray, CS, Martin, L, Deas, J, Cashin, E, Poletti, G, Simpson, A, Woodcock, AA, Custovic, A
Arch Dis Child. 2004;89( 6).
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Abstract
AIMS: To investigate the relation between parentally reported wheeze (unconfirmed), physician confirmed wheeze, and subsequent lung function.METHODS: Children at risk of allergic disease (one parent atopic) wererecruited antenatally and followed prospectively from birth. During thefirst three years of life parents were asked to contact the study team iftheir child was wheezy. The presence of wheeze was confirmed or not by theprimary care or study physician. Respiratory questionnaire and specificairway resistance measurement (sR(aw), body plethysmograph) were completedat age 3 years. RESULTS: A total of 454 children were followed from birthto 3 years of age. One hundred and eighty six (40.9%) of the parentsreported their child wheezing in the first three years of life, and in 130(28.6%) the wheeze was confirmed. A total of 428 children attended thethree year clinic review, of whom 274 (64%) successfully carried out lungfunction tests. There was no significant difference in sR(aw) (kPa.s;geometric mean, 95% CI) between children who had never wheezed (n = 152;1.03, 1.00 to 1.06) and those with a parentally reported but unconfirmedwheeze (n = 36; 1.02, 0.96 to 1.07, p = 1.00). sR(aw) was significantlyhigher in children with a physician confirmed wheeze (n = 86; 1.17, 1.11to 1.22, p < 0.001) compared to those with no history of wheeze or withunconfirmed wheeze. CONCLUSIONS: Children with physician confirmed wheezehave significantly poorer lung function compared to those with parentallyreported but unconfirmed and those who have never wheezed. A proportion ofparents may have little understanding of what medical professionals meanby the term "wheeze".
Keyword(s)
Analysis of Variance; Child, Preschool; Family Practice; Follow-Up Studies; Humans; Infant; Infant, Newborn; Parents; Prospective Studies; Research Support, Non-U.S. Gov't; diagnosis: Respiratory Sounds; methods: Respiratory Function Tests; physiopathology: Lung Diseases