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Exposure and sensitization to indoor allergens: association with lung function, bronchial reactivity, and exhaled nitric oxide measures in asthma.

Langley S, Goldthorpe S, Craven M, Morris J, Woodcock AA, Custovic A

J Allergy Clin Immunol. 2003;112( 2):362-8.

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Abstract

BACKGROUND: Exposure to high levels of allergens in sensitized asthmatic patients causes worsening of pulmonary function in experimental studies.Chronic exposure to lower, naturally occurring levels of allergens mightincrease the severity of asthma. OBJECTIVE: We sought to study theassociations between sensitization and exposure to common indoor allergens(dust mite, cat, and dog) in the home on pulmonary function, exhalednitric oxide (eNO), and airway reactivity in asthmatic patients. METHODS:Dust samples were collected from the living room carpet and mattress of311 subject's homes, and Der p 1, Fel d 1, and Can f 1 concentrations weremeasured by using ELISAs. Spirometry, nonspecific bronchial reactivity,and eNO were measured. RESULTS: Subjects both sensitized and exposed tohigh levels of sensitizing allergen had significantly lower FEV(1) percentpredicted values (mean, 83.7% vs 89.3%; mean difference, 5.6%; 95% CI,0.6%-10.6%; P =.03), higher eNO values (geometric mean [GM], 12.8 vs 8.7ppb; GM ratio, 0.7; 95% CI, 0.5-0.8; P =.001), and more severe airwaysreactivity (PD(20) GM, 0.25 vs 0.73 mg; GM ratio, 2.9; 95% CI, 1.6-5.0; P<.001) compared with subjects not sensitized and exposed. Nosignificant effect of the interaction between sensitization and exposurewas found for FEV(1) percent predicted and eNO values. However, there wasa significant effect of the interaction between sensitization and exposureto any allergen (P =.05) and between sensitization and exposure to catallergen (P =.04) for nonspecific bronchial reactivity. CONCLUSION:Asthmatic subjects who are exposed in their homes to allergens to whichthey are sensitized have a more severe form of the disease.

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Place of publication:
United States
Volume:
112( 2)
Start page:
362
End page:
8
Pagination:
362-8
Access state:
Active

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Record metadata

Manchester eScholar ID:
uk-ac-man-scw:1d9104
Created:
29th August, 2009, 14:54:59
Last modified:
29th September, 2015, 13:24:49

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