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Polymorphisms in the tumour necrosis factor gene are not associated with severity of inflammatory polyarthritis

Barton, A, Barton, A, Platt, H, Salway, F, Symmons, D, Barrett, EM, Bukhari, MAS, Lunt, M, Zeggini, E, Eyre, SS, Hinks, AM, Tellam, DJ, Brintnell, W, Ollier, WER, Worthington, J, Silman, AJ

Ann Rheum Dis. 2004;63, 3:280-284.

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Abstract

Background: Tumour necrosis factor alpha (TNF{alpha}) is a powerful inflammatory mediator in rheumatoid and other types of inflammatory arthritis. Polymorphisms within the TNF{alpha} gene have previously been investigated to determine their role in the aetiopathogenesis of rheumatoid arthritis (RA), but it is unclear whether reported associations are with susceptibility to, or severity of, disease. Objective: To examine the association between both individual TNF{alpha} single nucleotide polymorphisms (SNPs) and haplotypes with the development and severity of erosions by 5 years in patients with inflammatory polyarthritis (IP). Methods: 438 patients from the Norfolk Arthritis Register observational inception cohort of patients with IP were x rayed 5 years after disease onset. They were genotyped for nine SNPs mapping to the TNF{alpha} gene, using a SNaPshot primer extension assay. Haplotypes were constructed in patients with IP, who were compared for the presence and extent of erosions at 5 years. Results: No association between individual TNF{alpha} SNPs or haplotypes in the patients who developed erosions at 5 years compared with those who remained non-erosive was found. Restricting analysis to patients who satisfied ACR criteria for RA by 5 years did not affect the conclusions. Conclusion: The TNF{alpha} gene does not seem to be associated with severity as assessed by erosive outcome at 5 years in patients with IP

Bibliographic metadata

Type of resource:
Content type:
Publication type:
Publication form:
Published date:
Journal title:
Volume:
63, 3
Start page:
280
End page:
284
Pagination:
280-284
Digital Object Identifier:
10.1136/ard.2003.008680
Access state:
Active

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:1d9454
Created:
29th August, 2009, 15:02:38
Last modified:
20th July, 2015, 13:17:12

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