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- PMID: 23216877
- UKPMCID: 23216877
- DOI: 10.1111/micc.12027
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Ryanodine receptors, calcium signaling, and regulation of vascular tone in the cerebral parenchymal microcirculation.
Dabertrand, Fabrice; Nelson, Mark T; Brayden, Joseph E
Microcirculation (New York, N.Y. : 1994). 2013;20(4):307-16.
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Full-text held externally
- PMID: 23216877
- UKPMCID: 23216877
- DOI: 10.1111/micc.12027
Abstract
The cerebral blood supply is delivered by a surface network of pial arteries and arterioles from which arise (parenchymal) arterioles that penetrate into the cortex and terminate in a rich capillary bed. The critical regulation of CBF, locally and globally, requires precise vasomotor regulation of the intracerebral microvasculature. This vascular region is anatomically unique as illustrated by the presence of astrocytic processes that envelope almost the entire basolateral surface of PAs. There are, moreover, notable functional differences between pial arteries and PAs. For example, in pial VSMCs, local calcium release events ("calcium sparks") through ryanodine receptor (RyR) channels in SR membrane activate large conductance, calcium-sensitive potassium channels to modulate vascular diameter. In contrast, VSMCs in PAs express functional RyR and BK channels, but under physiological conditions, these channels do not oppose pressure-induced vasoconstriction. Here, we summarize the roles of ryanodine receptors in the parenchymal microvasculature under physiologic and pathologic conditions, and discuss their importance in the control of CBF.
Bibliographic metadata
- P01 HL095488, NHLBI NIH HHS, United States
- P01HL095488, NHLBI NIH HHS, United States
- R01 HL044455, NHLBI NIH HHS, United States
- R01 HL058231, NHLBI NIH HHS, United States
- R01HL44455, NHLBI NIH HHS, United States
- R01HL58231, NHLBI NIH HHS, United States
- R37 DK053832, NIDDK NIH HHS, United States
- R37DK053832, NIDDK NIH HHS, United States