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Recognizable phenotypes associated with intracranial calcification.

Livingston, John H; Stivaros, Stavros; van der Knaap, Marjo S; Crow, Yanick J

Developmental medicine and child neurology. 2013;55(1):46-57.

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Abstract

AIM: In this observational study, we adopted a systematic approach to the radiological phenotyping of disorders associated with intracranial calcification, with the aim of determining if characteristic patterns could be defined as an aid to the future diagnosis of known conditions and the identification of new disorders. METHOD: A cranial imaging-based scoring system was devised using both computed tomography and magnetic resonance imaging data. Patients were grouped into diagnostic categories where a definitive molecular diagnosis was known, or where the clinical and radiological features suggested a specific diagnosis. For patients in whom the diagnosis was unknown, subgroups were defined according to shared radiological features. RESULTS: Data on 244 scans from 119 patients were analysed. A specific diagnosis was available for 59 patients (31 males, 28 females; median age 50 mo, range 1 wk to 54 y). These were as follows (number of patients in brackets): Aicardi-Goutières syndrome (33), cerebroretinal microangiopathy with calcification and cysts (10), band-like calcification with simplified gyration and polymicrogyria (6), COL4A1-related disease (3), Degos disease (2), Krabbe disease (2), Alexander disease (1), mitochondrial disease (1), and tetrasomy 15 (1). In 60 patients the aetiology was unknown. Within this group, subsets demonstrating shared characteristics suggestive of a specific calcification phenotype could be identified. INTERPRETATION: This study confirms the value of a systematic approach to radiological phenotyping of disorders associated with intracranial calcification.

Bibliographic metadata

Type of resource:
Content type:
Publication type:
Published date:
Abbreviated journal title:
ISSN:
Place of publication:
England
Volume:
55
Issue:
1
Pagination:
46-57
Digital Object Identifier:
10.1111/j.1469-8749.2012.04437.x
Pubmed Identifier:
23121296
Access state:
Active

Institutional metadata

University researcher(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:203139
Created by:
Crow, Yanick
Created:
30th July, 2013, 13:16:51
Last modified by:
Crow, Yanick
Last modified:
30th July, 2013, 13:16:51

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