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From initial case report to randomized clinical trial through 20 years of research in periodontal therapy.

Nieri, Michele; Saletta, Daniele; Buti, Jacopo; Pagliaro, Umberto; Guidi, Luisa; Rotundo, Roberto; Prato, Giovanpaolo Pini

Journal of clinical periodontology. 2009;36(1):39-43.

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Abstract

AIM: Case reports (CRs) are often the first publication of a new treatment, but randomized clinical trials (RCTs) are needed to confirm the data. The aim of this study was to evaluate how many therapies published as CRs were followed by RCTs of these therapies over a 20-year period. MATERIAL AND METHODS: Two researchers conducted a search through international periodontal journals and found the CRs on periodontal treatments published from 1984 to 1986. Subsequent electronic searches made it possible to verify how many of the treatments published as CRs were also investigated through RCTs over the following 20 years. RESULTS: Thirty-one different therapies were selected out of the 33 published CRs; 15 (48%) of these 31 treatments were investigated by RCTs over the next 20 years. CONCLUSIONS: As 52% of the CRs were not validated by RCTs, practitioners should view their results with caution.

Bibliographic metadata

Type of resource:
Content type:
Publication type:
Published date:
Abbreviated journal title:
ISSN:
Place of publication:
Denmark
Volume:
36
Issue:
1
Pagination:
39-43
Digital Object Identifier:
10.1111/j.1600-051X.2008.01341.x
Pubmed Identifier:
19021788
Pii Identifier:
CPE1341
Access state:
Active

Institutional metadata

University researcher(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:205269
Created by:
Buti, Jacopo
Created:
19th August, 2013, 09:57:32
Last modified by:
Buti, Jacopo
Last modified:
19th August, 2013, 09:57:32

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