Related resources
Full-text held externally
- PMID: 23604856
- UKPMCID: 23604856
- DOI: 10.1007/s10689-013-9615-1
Search for item elsewhere
University researcher(s)
Academic department(s)
Cancer risk in Lynch Syndrome.
Barrow, Emma; Hill, James; Evans, D Gareth
Familial cancer. 2013;12(2):229-40.
Access to files
Full-text and supplementary files are not available from Manchester eScholar. Full-text is available externally using the following links:
Full-text held externally
- PMID: 23604856
- UKPMCID: 23604856
- DOI: 10.1007/s10689-013-9615-1
Abstract
Lynch Syndrome, or hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant cancer predisposition syndrome caused by inactivating mutations in DNA mismatch repair genes. It accounts for 2-4Â % of all incident colorectal cancers. Mutation carriers are at risk of early onset colorectal cancer, endometrial cancer, and a spectrum of other tumours. Accurate estimation of cancer risk for mutation carriers is essential for counselling, and establishing appropriate screening guidelines. This study reviews the current data on cancer risk, and emerging risk reduction strategies.