Related resources
Search for item elsewhere
University researcher(s)
Academic department(s)
A linkage study in seven breast cancer families.
Teare, M D; Santibáñez-Koref, M F; Wallace, S A; White, G R; Evans, D G; Burnell, L D; Harris, M; Howell, A; Birch, J M
American journal of human genetics. 1993;52(4):786-8.
Access to files
Full-text and supplementary files are not available from Manchester eScholar. Full-text is available externally using the following links:
Abstract
Seven breast cancer families are examined for evidence of linkage to a site in the region of 17q12-q21, by using five markers. The families constitute a subset of a larger series of familial breast cancer; the seven families were selected because constitutional DNA was available on informative members, either from clinical samples or extracted from paraffin blocks. Two-point lod scores are reported. The maximum lod score, 0.8824, is obtained with marker NM23 at theta = 0. This is clearly not significant in itself; however, when taken in context with evidence from existing reports, it provides support for linkage to this region.