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- PMID: 1303261
- UKPMCID: 1303261
- DOI: 10.1038/ng1092-128
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Allele losses in the region 17q12-21 in familial breast and ovarian cancer involve the wild-type chromosome.
Smith, S A; Easton, D F; Evans, D G; Ponder, B A
Nature genetics. 1992;2(2):128-31.
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Full-text held externally
- PMID: 1303261
- UKPMCID: 1303261
- DOI: 10.1038/ng1092-128
Abstract
A predisposing gene for breast and ovarian cancer has recently been mapped to chromosome 17q12-21. If this gene is a tumour suppressor gene, allele losses would be expected in the tumours of affected family members and the losses should affect the wild-type chromosome, reflecting the need for inactivation of the wild-type allele at the predisposing locus. In four multiple case breast-ovarian cancer families, we have found that in each of nine tumours which showed allele losses, the losses were from the wild-type chromosome. This suggests that the putative 'breast-ovarian' cancer gene is indeed a tumour suppressor gene.