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Familial site-specific ovarian cancer is linked to BRCA1 on 17q12-21.
Steichen-Gersdorf, E; Gallion, H H; Ford, D; Girodet, C; Easton, D F; DiCioccio, R A; Evans, G; Ponder, M A; Pye, C; Mazoyer, S
American journal of human genetics. 1994;55(5):870-5.
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Abstract
In a study of nine families with "site-specific" ovarian cancer (criterion: three or more cases of epithelial ovarian cancer and no cases of breast cancer diagnosed at age < 50 years) we have obtained evidence of linkage to the breast-ovarian cancer susceptibility gene, BRCA1 on 17q12-21. If the risk of cancer in these families is assumed to be restricted to the ovary, the best estimate of the proportion of families linked to BRCA1 is .78 (95% confidence interval .32-1.0). If predisposition to both breast and ovarian cancer is assumed, the proportion linked is 1.0 (95% confidence interval .46-1.0). The linkage of familial site-specific ovarian cancer to BRCA1 indicates the possibility of predictive testing in such families; however, this is only appropriate in families where the evidence for linkage to BRCA1 is conclusive.