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Physical mapping of the NF2/meningioma region on human chromosome 22q12.

Ruttledge, M H; Xie, Y G; Han, F Y; Giovannini, M; Janson, M; Fransson, I; Werelius, B; Delattre, O; Thomas, G; Evans, G

Genomics. 1994;19(1):52-9.

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Abstract

Loss of genetic information from chromosome 22 has been implicated in the development of neurofibromatosis type 2, meningioma, and several other neoplasia. Molecular studies indicate that genes within chromosomal band 22q12 may be involved in tumorigenesis. We have mapped 29 loci into 16 groups in this region, using pulsed-field gel electrophoresis, fluorescence in situ suppression hybridization, and somatic cell hybrid mapping. The region spans more than 5 Mb of genomic DNA and contains the genes for neurofibromatosis type 2 and meningioma. The order of loci presented here provides the framework for the fine mapping of this region using cosmids and yeast artificial chromosomes, and it facilitates the speedy cloning of novel genes from 22q12.

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Place of publication:
UNITED STATES
Volume:
19
Issue:
1
Pagination:
52-9
Pubmed Identifier:
8188242
Pii Identifier:
S0888754384710123
Access state:
Active

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Record metadata

Manchester eScholar ID:
uk-ac-man-scw:210875
Created by:
Evans, Gareth
Created:
12th October, 2013, 14:52:12
Last modified by:
Evans, Gareth
Last modified:
12th October, 2013, 14:52:12

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