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Docking domains and substrate-specificity determination for MAP kinases.

Sharrocks, A D; Yang, S H; Galanis, A

Trends in biochemical sciences. 2000;25(9):448-53.

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Abstract

Signalling specificity in eukaryotic cells is maintained by several mechanisms. One mechanism by which mitogen-activated protein (MAP) kinases ensure their specificity of action is by interacting with their substrates through docking domains. These docking domains recruit the kinases to the correct substrates and enhance their fidelity and efficiency of action. Additional specificity determinants in the substrates serve to enhance the specificity of substrate phosphorylation by MAP kinases further.

Bibliographic metadata

Type of resource:
Content type:
Publication type:
Published date:
Abbreviated journal title:
ISSN:
Place of publication:
ENGLAND
Volume:
25
Issue:
9
Pagination:
448-53
Pubmed Identifier:
10973059
Pii Identifier:
S0968-0004(00)01627-3
Access state:
Active

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University researcher(s):
Academic department(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:218074
Created by:
Yang, Shen-Hsi
Created:
26th January, 2014, 16:43:57
Last modified by:
Yang, Shen-Hsi
Last modified:
26th January, 2014, 16:43:57

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