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Full-text held externally
- PMID: 24372444
- UKPMCID: 24372444
- DOI: 10.1586/1744666X.2014.873701
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Treating moderate to severe psoriasis - best use of biologics.
Lynch, Maeve; Kirby, Brian; Warren, Richard B
Expert review of clinical immunology. 2014;10(2):269-79.
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Full-text held externally
- PMID: 24372444
- UKPMCID: 24372444
- DOI: 10.1586/1744666X.2014.873701
Abstract
This review focuses on the efficacy, safety and best use of biologic agents in moderate-to-severe psoriasis. Recommendations from two recent guidelines are summarised. The NICE Guidelines 2012 provide recommendations on best practice for prescribing biologics. The German S3 Guidelines are based on a systematic review of published studies and report the efficacy of biologics and guidelines for treatment. Data on the safety of biologics are available for up to 5 years in psoriasis and are on the whole reassuring. Registry data is evolving and will provide data on safety to help inform long-term monitoring of patients with psoriasis on biologics agents. New anti-interleukin-17 (IL17) and anti-IL17RA biologics are in Phase 3 clinical trials and may prove to be more effective than existing biologics.