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- PMID: 24749725
- UKPMCID: 24749725
- DOI: 10.1111/bjd.13060
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Safety of biologic therapies for psoriasis on reproductive potential and outcomes in males and females.
Yiu, Z Z N; Griffiths, C E M; Warren, R B
The British journal of dermatology. 2014;.
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Full-text held externally
- PMID: 24749725
- UKPMCID: 24749725
- DOI: 10.1111/bjd.13060
Abstract
The effects of biologic therapies for psoriasis on pregnancy outcomes, lactation and male fertility and mutagenicity are common concerns in the clinical setting. There is relatively little evidence to guide clinician and patient. Here, we review the safety profile of the commonly used biologic therapies for psoriasis in individuals of reproductive potential. Safety data are derived from large scale registries, adverse-event reporting databases, clinical trials and case reports. We assess the effect of each therapy on: (i) adverse pregnancy outcomes, including congenital malformations, and lactation with maternal administration; and (ii) male fertility and potential mutagenicity with paternal administration. We provide applicable guidance to inform clinician and patient before and after conception. This article is protected by copyright. All rights reserved.