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- DOI: 10.1016/j.clim.2014.02.011
- PMID: 24589748
- UKPMCID: 24589748
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In Black Africans with rheumatoid arthritis, ACPA recognize citrullinated fibrinogen and the derived peptides α36-50Cit38,42 and β60-74Cit60,72,74, like in Caucasians.
Nogueira, Leonor; Cornillet, Martin; Singwe-Ngandeu, Madeleine; Viatte, Sebastien; Bas, Sylvette; Gabay, Cem; Serre, Guy
Clinical immunology (Orlando, Fla.). 2014;152(1-2):58-64.
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Full-text held externally
- DOI: 10.1016/j.clim.2014.02.011
- PMID: 24589748
- UKPMCID: 24589748
Abstract
Well documented in Caucasians and Asians, the diagnostic value of anti-CCP2 antibodies has been confirmed in Black African populations. However, autoantibodies to other citrullinated peptides/proteins and their fine specificities have not yet been studied. Here, we show that in Cameroonian patients, anti-citrullinated fibrinogen autoantibodies (AhFibA) are sensitive (73%) diagnostic markers for RA. We also determine that autoantibodies directed to α36-50Cit38,42 or β60-74Cit60,72,74 peptides which bear the immunodominant epitopes of citrullinated fibrin, are present in similar proportions in Black Africans and Caucasians with 25/56 (45%) and 41/56 (73%) positive RA-sera in Cameroonians, respectively. They also account for almost all the AhFibA reactivities since 38/41 (93%) AhFibA-positive sera contain anti-α36-50Cit38,42 and/or anti-β60-74Cit60,72,74 autoantibodies. Finally, HLA-DRB1 SE alleles were associated with higher titres of AhFibA and anti-β60-74Cit60,72,74 autoantibodies. In the genetic and environmental backgrounds of Black Africans, AhFibA are a hallmark of RA like in Caucasians, moreover they recognize the same fibrin epitopes.
Keyword(s)
Anti-citrullinated protein autoantibodies (ACPA); B-cell epitopes; Black Africans; Citrullinated fibrin; Rheumatoid arthritis