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Bone turnover markers predict hip bone loss in elderly European men: results of the European Male Ageing Study (EMAS).

Gielen, E; O'Neill, T; Pye, S; Adams, J; Ward, K; Wu, F; Laurent, M; Claessens, F; Boonen, S; Vanderschueren, D; Verschueren, S

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2015;26(2):617-627.

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Abstract

The aim of this study was to determine whether bone turnover markers (BTMs) predict changes in areal bone mineral density (aBMD) in middle-aged and elderly European men. Older men with high bone turnover are at a higher risk of accelerated hip bone loss, but the clinical utility of BTMs in individuals is limited.INTRODUCTION: Prospective studies on the value of BTMs to predict changes in aBMD in men are few and conflicting. The aim of this study was to determine whether BTMs predict changes in aBMD in middle-aged and elderly European men. METHODS: In 487 men aged 40-79 years from the European Male Ageing Study (EMAS), BTMs were assessed at baseline and dual-energy X-ray absorptiometry (DXA) at the lumbar spine (LS), femoral neck (FN) and total hip (TH) was performed at baseline and after a mean follow-up of 4.3 years. RESULTS: The mean aBMD decreased by 0.32 %/year at FN and 0.22 %/year at TH and increased by 0.32 %/year at LS. Higher baseline levels of β C-terminal cross-linked telopeptide (β-CTX) and N-terminal propeptide of type I procollagen (PINP) were significantly associated with higher loss of hip aBMD in the whole cohort and men aged 60-79 years. These associations remained significant after adjustment for age, centre and body mass index (BMI). Men aged 60-79 years with β-CTX in the upper quintile were more likely of being in the upper quintile of annual percentage (%) aBMD loss at FN (OR = 4.27; 95% CI = 2.09-8.73) and TH (OR = 3.73; 95% CI = 1.84-7.57). The positive predictive value (PPV) was 46 % at both hip sites. CONCLUSION: Older men with high bone turnover have a higher risk of accelerated hip bone loss, but the PPV is low. BTMs are therefore unlikely to be of clinical utility in predicting accelerated hip bone loss in individual subjects.

Bibliographic metadata

Type of resource:
Content type:
Publication status:
Published
Publication type:
Publication form:
Published date:
Abbreviated journal title:
ISSN:
Volume:
26
Issue:
2
Start page:
617
End page:
627
Total:
10
Pagination:
617-627
Digital Object Identifier:
10.1007/s00198-014-2884-1
Pubmed Identifier:
25224294
Attached files embargo period:
Immediate release
Attached files release date:
23rd September, 2014
Access state:
Active

Institutional metadata

University researcher(s):
Academic department(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:234408
Created by:
Ingram, Mary
Created:
23rd September, 2014, 14:54:53
Last modified by:
Ingram, Mary
Last modified:
20th February, 2015, 16:23:30

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