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Potassium Channels and Neurovascular Coupling

Dunn KM, Nelson MT

Circulation Journal. 2010;74(4):608-616.

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Abstract

Neuronal activity is communicated to the cerebral vasculature so that adequate perfusion of brain tissue is maintained at all levels of neuronal metabolism. An increase in neuronal activity is accompanied by vasodilation and an increase in local cerebral blood flow. This process, known as neurovascular coupling (NVC) or functional hyperemia, is essential for cerebral homeostasis and survival. Neuronal activity is encoded in astrocytic Ca(2+) signals that travel to astrocytic processes (;endfeet') encasing parenchymal arterioles within the brain. Astrocytic Ca(2+) signals cause the release of vasoactive substances to cause relaxation, and in some circumstances contraction, of the smooth muscle cells (SMCs) of parenchymal arterioles to modulate local cerebral blood flow. Activation of potassium channels in the SMCs has been proposed to mediate NVC. Here, the current state of knowledge of NVC and potassium channels in parenchymal arterioles is reviewed.

Bibliographic metadata

Type of resource:
Content type:
Publication status:
Accepted
Publication type:
Author list:
Published date:
Language:
eng
Journal title:
Abbreviated journal title:
ISSN:
Volume:
74
Issue:
4
Start page:
608
End page:
616
Total:
8
Pagination:
608-616
Digital Object Identifier:
10.1253/circj.CJ-10-0174
Attached files embargo period:
Immediate release
Attached files release date:
30th September, 2014
Access state:
Active

Institutional metadata

University researcher(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:235618
Created by:
Nelson, Mark
Created:
30th September, 2014, 20:21:15
Last modified by:
Nelson, Mark
Last modified:
30th September, 2014, 20:21:15

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