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- PMID: 21075611
- UKPMCID: 21075611
- DOI: 10.1016/j.euroneuro.2010.10.004
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Differential gene expression in mutant mice overexpressing or deficient in the serotonin transporter: a focus on urocortin 1.
Fabre, Véronique; Massart, Renaud; Rachalski, Adeline; Jennings, Katie; Brass, Andrew; Sharp, Trevor; Lesch, Klaus-Peter; Lanfumey, Laurence; Hamon, Michel
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2011;21(1):33-44.
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Full-text held externally
- PMID: 21075611
- UKPMCID: 21075611
- DOI: 10.1016/j.euroneuro.2010.10.004
Abstract
Transcriptome analyses were performed in the anterior raphe area of mutant mice deficient in the serotonin transporter (5-HTT KO) or overexpressing this protein (5-HTT TG), which exhibit opposite changes in anxiety-related behavior. Among genes with altered expression, the gene encoding the neuropeptide urocortin 1 was down-regulated in 5-HTT KO and up-regulated in 5-HTT TG mice. Expression of the gene encoding cocaine-and-amphetamine-related-peptide, which colocalizes with urocortin 1, was also increased in 5-HTT TG mutants. Real-time RT-PCR confirmed these data and immunoautoradiographic labeling showed that parallel changes in neuropeptide levels were confined to the non-preganglionic Edinger-Westphal nucleus. Thus, 5-HTT expression correlates with that of urocortin 1, suggesting that this peptide can be involved in the behavioral changes observed in 5-HTT mutant mice.