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Uptake of tamoxifen in consecutive premenopausal women under surveillance in a high-risk breast cancer clinic.

Donnelly, L S; Evans, D G; Wiseman, J; Fox, J; Greenhalgh, R; Affen, J; Juraskova, I; Stavrinos, P; Dawe, S; Cuzick, J; Howell, A

British journal of cancer. 2014;110(7):1681-7.

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Abstract

BACKGROUND: Randomised trials of tamoxifen versus placebo indicate that tamoxifen reduces breast cancer risk by approximately 33%, yet uptake is low. Approximately 10% of women in our clinic entered the IBIS-I prevention trial. We assess the uptake of tamoxifen in a consecutive series of premenopausal women not in a trial and explore the reasons for uptake through interviews. METHODS: All eligible women between 33 and 46 years at ≥17% lifetime risk of breast cancer and undergoing annual mammography in our service were invited to take a 5-year course of tamoxifen. Reasons for accepting (n=15) or declining (n=15) were explored using semi-structured interviews. RESULTS: Of 1279 eligible women, 136 (10.6%) decided to take tamoxifen. Women >40 years (74 out of 553 (13.4%)) and those at higher non-BRCA-associated risk were more likely to accept tamoxifen (129 out of 1109 (11.6%)). Interviews highlighted four themes surrounding decision making: perceived impact of side effects, the impact of others' experience on beliefs about tamoxifen, tamoxifen as a 'cancer drug', and daily reminder of cancer risk. CONCLUSIONS: Tamoxifen uptake was similar to previously ascertained uptake in a randomised controlled trial (IBIS-I). Concerns were similar in women who did or did not accept tamoxifen. Decision making appeared to be embedded in the experience of significant others.

Bibliographic metadata

Type of resource:
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Publication type:
Published date:
Journal title:
Abbreviated journal title:
ISSN:
Place of publication:
England
Volume:
110
Issue:
7
Pagination:
1681-7
Digital Object Identifier:
10.1038/bjc.2014.109
Pubmed Identifier:
24594998
Pii Identifier:
bjc2014109
Access state:
Active

Institutional metadata

University researcher(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:239118
Created by:
Evans, Gareth
Created:
6th November, 2014, 07:32:34
Last modified by:
Evans, Gareth
Last modified:
6th November, 2014, 07:32:34

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