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- PMID: 24136669
- UKPMCID: 24136669
- DOI: 10.1007/s10549-013-2729-1
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The impact of pregnancy on breast cancer survival in women who carry a BRCA1 or BRCA2 mutation.
Valentini, Adriana; Lubinski, Jan; Byrski, Tomasz; Ghadirian, Parviz; Moller, Pal; Lynch, Henry T; Ainsworth, Peter; Neuhausen, Susan L; Weitzel, Jeffrey; Singer, Christian F; Olopade, Olufunmilayo I; Saal, Howard; Lyonnet, Dominique Stoppa; Foulkes, William D; Kim-Sing, Charmaine; Manoukian, Siranoush; Zakalik, Dana; Armel, Susan; Senter, Leigha; Eng, Charis; Grunfeld, Eva; Chiarelli, Anna M; Poll, Aletta; Sun, Ping; Narod, Steven A;
Breast cancer research and treatment. 2013;142(1):177-85.
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Full-text held externally
- PMID: 24136669
- UKPMCID: 24136669
- DOI: 10.1007/s10549-013-2729-1
Abstract
Physicians are often approached by young women with a BRCA mutation and a recent history of breast cancer who wish to have a baby. They wish to know if pregnancy impacts upon their future risks of cancer recurrence and survival. To date, there is little information on the survival experience of women who carry a mutation in one of the BRCA genes and who become pregnant. From an international multi-center cohort study of 12,084 women with a BRCA1 or BRCA2 mutation, we identified 128 case subjects who were diagnosed with breast cancer while pregnant or who became pregnant after a diagnosis of breast cancer. These women were age-matched to 269 mutation carriers with breast cancer who did not become pregnant (controls). Subjects were followed from the date of breast cancer diagnosis until the date of last follow-up or death from breast cancer. The Kaplan-Meier method was used to estimate 15-year survival rates. The hazard ratio for survival associated with pregnancy was calculated using a left-truncated Cox proportional hazard model, adjusting for other prognostic factors. Among women who were diagnosed with breast cancer when pregnant or who became pregnant thereafter, the 15-year survival rate was 91.5 %, compared to a survival of 88.6 % for women who did not become pregnant (adjusted hazard ratio = 0.76; 95 % CI 0.31-1.91; p = 0.56). Pregnancy concurrent with or after a diagnosis of breast cancer does not appear to adversely affect survival among BRCA1/2 mutation carriers.
Bibliographic metadata
- Valentini, Adriana
- Lubinski, Jan
- Byrski, Tomasz
- Ghadirian, Parviz
- Moller, Pal
- Lynch, Henry T
- Ainsworth, Peter
- Neuhausen, Susan L
- Weitzel, Jeffrey
- Singer, Christian F
- Olopade, Olufunmilayo I
- Saal, Howard
- Lyonnet, Dominique Stoppa
- Foulkes, William D
- Kim-Sing, Charmaine
- Manoukian, Siranoush
- Zakalik, Dana
- Armel, Susan
- Senter, Leigha
- Eng, Charis
- Grunfeld, Eva
- Chiarelli, Anna M
- Poll, Aletta
- Sun, Ping
- Narod, Steven A
- Gronwald, Jacek
- Cybulski, Cezary
- Huzarski, Tomasz
- Robidoux, Andre
- Offit, Kenneth
- Gershoni-Baruch, Ruth
- Isaacs, Claudine
- Tung, Nadine
- Rosen, Barry
- Demsky, Rochelle
- McCuaig, Jeanna
- Eisen, Andrea
- Bordeleau, Louise
- Karlan, Beth
- Garber, Judy
- Gilchrist, Dawna
- Eng, Charis
- Couch, Fergus
- Evans, Gareth
- Kwong, Ava
- Maehle, Lovise
- Friedman, Eitan
- McKinnon, Wendy
- Wood, Marie
- Daly, Mary
- Blum, Joanne L
- Robson, Mark
- Chudley, Albert
- Panchal, Seema
- McLennan, Jane
- Pasini, Barabara
- Rennert, Gad
- Lunn, John
- Fallen, Taya
- Rayson, Daniel
- Smith, Marissa
- Ginsburg, Ophira
- Lemire, Edmond
- Meschino, Wendy
- Vadaparampil, Susan
- Euhus, David
- Costalas, Josephine Wagner
- Donenberg, Talia
- Kurz, Raluca N
- Friedman, Susan
- Sweet, Kevin
- Cullinane, Carey A
- Reilly, Robert E
- Kotsopoulos, Joanne
- Nanda, Sonia
- Metcalfe, Kelly