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- PMID: 24610876
- UKPMCID: 24610876
- DOI: 10.1093/infdis/jiu139
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Risk of newly detected infections and cervical abnormalities in women seropositive for naturally acquired human papillomavirus type 16/18 antibodies: analysis of the control arm of PATRICIA.
Castellsagué, Xavier; Naud, Paulo; Chow, Song-Nan; Wheeler, Cosette M; Germar, Maria Julieta V; Lehtinen, Matti; Paavonen, Jorma; Jaisamrarn, Unnop; Garland, Suzanne M; Salmerón, Jorge; Apter, Dan; Kitchener, Henry; Teixeira, Julio C; Skinner, S Rachel; Limson, Genara; Szarewski, Anne; Romanowski, Barbara; Aoki, Fred Y; Schwarz, Tino F; Poppe, Willy A J; Bosch, F Xavier; de Carvalho, Newton S; Peters, Klaus; Tjalma, Wiebren A A; Safaeian, Mahboobeh; Raillard, Alice; Descamps, Dominique; Struyf, Frank; Dubin, Gary; Rosillon, Dominique; Baril, Laurence
The Journal of infectious diseases. 2014;210(4):517-34.
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Full-text held externally
- PMID: 24610876
- UKPMCID: 24610876
- DOI: 10.1093/infdis/jiu139
Abstract
BACKGROUND: We examined risk of newly detected human papillomavirus (HPV) infection and cervical abnormalities in relation to HPV type 16/18 antibody levels at enrollment in PATRICIA (Papilloma Trial Against Cancer in Young Adults; NCT00122681). METHODS: Using Poisson regression, we compared risk of newly detected infection and cervical abnormalities associated with HPV-16/18 between seronegative vs seropositive women (15-25 years) in the control arm (DNA negative at baseline for the corresponding HPV type [HPV-16: n = 8193; HPV-18: n = 8463]). RESULTS: High titers of naturally acquired HPV-16 antibodies and/or linear trend for increasing antibody levels were significantly associated with lower risk of incident and persistent infection, atypical squamous cells of undetermined significance or greater (ASCUS+), and cervical intraepithelial neoplasia grades 1/2 or greater (CIN1+, CIN2+). For HPV-18, although seropositivity was associated with lower risk of ASCUS+ and CIN1+, no association between naturally acquired antibodies and infection was demonstrated. Naturally acquired HPV-16 antibody levels of 371 (95% confidence interval [CI], 242-794), 204 (95% CI, 129-480), and 480 (95% CI, 250-5756) EU/mL were associated with 90% reduction of incident infection, 6-month persistent infection, and ASCUS+, respectively. CONCLUSIONS: Naturally acquired antibodies to HPV-16, and to a lesser extent HPV-18, are associated with some reduced risk of subsequent infection and cervical abnormalities associated with the same HPV type.
Keyword(s)
HPV; cervical abnormality; infection; naturally acquired antibodies; risk reduction
Bibliographic metadata
- Castellsagué, Xavier
- Naud, Paulo
- Chow, Song-Nan
- Wheeler, Cosette M
- Germar, Maria Julieta V
- Lehtinen, Matti
- Paavonen, Jorma
- Jaisamrarn, Unnop
- Garland, Suzanne M
- Salmerón, Jorge
- Apter, Dan
- Kitchener, Henry
- Teixeira, Julio C
- Skinner, S Rachel
- Limson, Genara
- Szarewski, Anne
- Romanowski, Barbara
- Aoki, Fred Y
- Schwarz, Tino F
- Poppe, Willy A J
- Bosch, F Xavier
- de Carvalho, Newton S
- Peters, Klaus
- Tjalma, Wiebren A A
- Safaeian, Mahboobeh
- Raillard, Alice
- Descamps, Dominique
- Struyf, Frank
- Dubin, Gary
- Rosillon, Dominique
- Baril, Laurence