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Nanofi brillar Peptide Hydrogels for the Immobilization of Biocatalysts for Chemical Transformations

Hickling, Christopher; Toogood, Helen S; Saiani, Alberto; Scrutton, Nigel S; Miller, Aline F

Macromolecular Rapid Communications. 2014;35(9):868-874.

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Abstract

Enzymes are attractive, green alternatives to chemical catalysts within the industrial sector, but their robustness to environmental conditions needs optimizing. Here, an enzyme is tagged chemically and recombinantly with a self-assembling peptide that allows the conjugate to spontaneously assemble with pure peptide to form -sheet-rich nanofibers decorated with tethered enzyme. Above a critical concentration, these fibers entangle and form a 3D hydrogel. The immobilized enzyme catalyzes chemical transformations and critically its stability is increased significantly where it retains activity after exposure to high temperatures (90 degrees C) and long storage times (up to 12 months).

Bibliographic metadata

Type of resource:
Content type:
Publication status:
Accepted
Publication type:
Publication form:
Published date:
ISSN:
Volume:
35
Issue:
9
Start page:
868
End page:
874
Total:
7
Pagination:
868-874
Digital Object Identifier:
10.1002/marc.201400027
ISI Accession Number:
WOS:000335579100002
Related website(s):
  • Related website <Go to ISI>://WOS:000335579100002
General notes:
  • Times Cited: 0
Attached files embargo period:
Immediate release
Attached files release date:
21st January, 2015
Access state:
Active

Institutional metadata

University researcher(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:248663
Created by:
Saiani, Alberto
Created:
21st January, 2015, 14:32:58
Last modified by:
Saiani, Alberto
Last modified:
21st January, 2015, 20:23:59

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