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The role of serotonin in reward, punishment and behavioural inhibition in humans: Insights from studies with acute tryptophan depletion

Faulkner, P., Deakin, J.F.W

Neuroscience & Biobehavioral Reviews. 2014;46:365-378.

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Abstract

Deakin and Graeff proposed that forebrain 5-hydroxytryptamine (5-HT) projections are activated by aversive events and mediate anticipatory coping responses including avoidance learning and suppression of the fight-flight escape/panic response. Other theories proposed 5-HT mediates aspects of behavioural inhibition or reward. Most of the evidence comes from rodent studies. We review 36 experimental studies in humans in which the technique of acute tryptophan depletion (ATD) was used to explicitly address the role of 5-HT in response inhibition, punishment and reward. ATD did not cause disinhibition of responding in the absence of rewards or punishments (9 studies). A major role for 5-HT in reward processing is unlikely but further tests are warranted by some ATD findings. Remarkably, ATD lessened the ability of punishments (losing points or notional money) to restrain behaviour without affecting reward processing in 7 studies. Two of these studies strongly indicate that ATD blocks 5-HT mediated aversively conditioned Pavlovian inhibition and this can explain a number of the behavioural effects of ATD.

Bibliographic metadata

Type of resource:
Content type:
Publication status:
Accepted
Publication type:
Published date:
Language:
eng
Abbreviated journal title:
ISSN:
Publisher:
Volume:
46
Start page:
365
End page:
378
Total:
13
Pagination:
365-378
Attached files embargo period:
Immediate release
Attached files release date:
23rd January, 2015
Access state:
Active

Institutional metadata

University researcher(s):
Academic department(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:250069
Created by:
Deakin, Bill
Created:
23rd January, 2015, 16:02:03
Last modified by:
Deakin, Bill
Last modified:
17th December, 2015, 08:08:20

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