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New visual information processing abnormality biomarker for the diagnosis of Schizophrenia.

Koychev, Ivan; El-Deredy, Wael; Deakin, John Francis William

Expert opinion on medical diagnostics. 2011;5(4):357-368.

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Abstract

INTRODUCTION: Schizophrenia is currently diagnosed on the basis of patient reports and clinical observations. A diagnosis based on aetiology is inherently more reliable due to being closer to the disease process than the overt clinical manifestations. Accordingly, recent research in schizophrenia has focused on the development of biomarkers in a bit to improve the reliability and neurobiological relevance of the diagnosis. Visual information processing is one of these promising fields of recent biomarker research. AREAS COVERED: This article provides an overview of the available literature regarding deficits in schizophrenia detectable through psychophysical (contrast and motion sensitivity, visual backward-masking), ERP (P1 and N1 visual evoked potentials) and oscillatory (signal power and phase-locking factor of evoked oscilations) measures and their validity as trait or state biomarkers of the disease. The methodology included a search on articles related to visual information processing in schizophrenia on the PubMed database. EXPERT OPINION: Biomarker research in schizophrenia is a rapidly expanding area. Evidence exists to suggest that both psychotic and manic symptoms are associated with visual processing abnormalities. A specific impairment confined to the magnocellular component of the visual system might be a trait biomarker of schizophrenia.

Bibliographic metadata

Type of resource:
Content type:
Publication type:
Published date:
Abbreviated journal title:
ISSN:
Volume:
5
Issue:
4
Pagination:
357-368
Digital Object Identifier:
10.1517/17530059.2011.586029
Pubmed Identifier:
22003364
Funder acknowledgement:
Access state:
Active

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Academic department(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:256099
Created by:
Deakin, Bill
Created:
29th January, 2015, 14:27:31
Last modified by:
Deakin, Bill
Last modified:
29th January, 2015, 14:27:31

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