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The relation of MRI-detected structural damage in the medial and lateral patellofemoral joint to knee pain: the Multicenter and Framingham Osteoarthritis Studies.

Stefanik, J J; Gross, K D; Guermazi, A; Felson, D T; Roemer, F W; Zhang, Y; Niu, J; Segal, N A; Lewis, C E; Nevitt, M; Neogi, T

Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2015;23(4):565-570.

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Abstract

OBJECTIVE: To examine the relation of cartilage loss and bone marrow lesions (BMLs) in the medial and lateral patellofemoral joint (PFJ) to knee pain. METHODS: We categorized the location of full-thickness cartilage loss and BMLs in the PFJ on knee magnetic resonance imaging (MRIs) from the Multicenter Osteoarthritis (MOST) and Framingham Osteoarthritis (FOA) Studies as no damage, isolated medial, isolated lateral, or both medial and lateral (mixed). We determined the relation of MRI lesions in each PFJ region to prevalent knee pain. Differences in knee pain severity were compared among categories of PFJ full-thickness cartilage loss and BMLs using quantile regression. RESULTS: In MOST (n = 1137 knees), compared with knees without full-thickness cartilage loss, knees with isolated lateral or mixed PFJ full-thickness cartilage loss had 1.9 (1.3, 2.8) and 1.9 (1.2, 2.9) times the odds of knee pain, respectively, while isolated medial cartilage loss had no association with knee pain. BMLs in both the medial and lateral PFJ had 1.5 (1.1, 2.0) times the odds of knee pain compared with knees without BMLs. Knee pain severity was lowest in knees with isolated medial PFJ cartilage loss or BMLs. In FOA (n = 934 knees), neither isolated medial nor lateral cartilage loss was associated with knee pain, whereas isolated BMLs in either region were associated with pain. CONCLUSIONS: Results were not completely concordant but suggest that knee pain risk and severity is greatest with cartilage loss isolated to (MOST) or inclusive of (MOST and FOA) the lateral PFJ. While BMLs in either the medial or lateral PFJ are related to pain.

Bibliographic metadata

Type of resource:
Content type:
Publication status:
Published
Publication type:
Publication form:
Published date:
Abbreviated journal title:
ISSN:
Volume:
23
Issue:
4
Start page:
565
End page:
570
Total:
5
Pagination:
565-570
Digital Object Identifier:
10.1016/j.joca.2014.12.023
Pubmed Identifier:
25575967
Pii Identifier:
S1063-4584(14)01397-1
Attached files embargo period:
Immediate release
Attached files release date:
9th February, 2015
Access state:
Active

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Academic department(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:258970
Created by:
Ingram, Mary
Created:
9th February, 2015, 11:12:41
Last modified by:
Ingram, Mary
Last modified:
24th March, 2015, 14:19:47

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