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    Modular Deconstruction Reveals the Dynamical and Physical Building Blocks of a Locomotion Motor Program.

    Bruno, Angela M; Frost, William N; Humphries, Mark D

    Neuron. 2015;86:304-318.

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    Abstract

    The neural substrates of motor programs are only well understood for small, dedicated circuits. Here we investigate how a motor program is constructed within a large network. We imaged populations of neurons in the Aplysia pedal ganglion during execution of a locomotion motor program. We found that the program was built from a very small number of dynamical building blocks, including both neural ensembles and low-dimensional rotational dynamics. These map onto physically discrete regions of the ganglion, so that the motor program has a corresponding modular organization in both dynamical and physical space. Using this dynamic map, we identify the population potentially implementing the rhythmic pattern generator and find that its activity physically traces a looped trajectory, recapitulating its low-dimensional rotational dynamics. Our results suggest that, even in simple invertebrates, neural motor programs are implemented by large, distributed networks containing multiple dynamical systems.

    Bibliographic metadata

    Type of resource:
    Content type:
    Publication status:
    Accepted
    Publication type:
    Published date:
    Journal title:
    Abbreviated journal title:
    ISSN:
    Volume:
    86
    Start page:
    304
    End page:
    318
    Total:
    14
    Pagination:
    304-318
    Digital Object Identifier:
    10.1016/j.neuron.2015.03.005
    Pubmed Identifier:
    25819612
    Pii Identifier:
    S0896-6273(15)00201-9
    Attached files embargo period:
    Immediate release
    Attached files release date:
    9th April, 2015
    Access state:
    Active

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    Record metadata

    Manchester eScholar ID:
    uk-ac-man-scw:262033
    Created by:
    Humphries, Mark
    Created:
    31st March, 2015, 11:53:52
    Last modified by:
    Humphries, Mark
    Last modified:
    18th November, 2015, 08:09:44

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