Related resources
Full-text held externally
- DOI: 10.1002/art.39436
- PMID: 26414125
- UKPMCID: 26414125
Search for item elsewhere
University researcher(s)
Academic department(s)
Patterns of Co-existing MRI lesions and incident knee osteoarthritis: The MOST Study.
Niu, Jingbo; Felson, David T; Neogi, Tuhina; Nevitt, Michael C; Guermazi, Ali; Roemer, Frank; Lewis, Cora E; Torner, James; Zhang, Yuqing
Arthritis & rheumatology (Hoboken, N.J.). 2015;67(12):3158-3165.
Access to files
Full-text and supplementary files are not available from Manchester eScholar. Full-text is available externally using the following links:
Full-text held externally
- DOI: 10.1002/art.39436
- PMID: 26414125
- UKPMCID: 26414125
Abstract
OBJECTIVE: To identify patterns of co-existing lesions on MRI in knees free of radiographic osteoarthritis and to examine their relation to incident disease. METHODS: From a prospective cohort study, the Multicenter Osteoarthritis Study, one knee per subject without radiographic osteoarthritis in both tibiofemoral and patellofemoral joints at baseline was selected and followed up to 84-months. We used a novel approach, latent class analysis, to group the constellation of MRI lesions in each joint, i.e., cartilage damage, bone marrow lesion, meniscal tear, meniscal extrusion, synovitis, and effusion, to a manageable number of subgroups. The association of these subgroups with incident radiographic osteoarthritis in the same joint was assessed using logistic regression. RESULTS: Among 885 eligible knees (mean age 60.5 years, 203 with incident disease in the tibiofemoral joint, 64 in the patellofemoral joint), four latent subgroups were identified in the tibiofemoral joint described briefly as: minimal lesions, mild lesions, moderate lesions (but limited meniscal lesions), and severe lesions. The odds ratios of incident disease in the tibiofemoral joint were 1.0, 5.6, 1.8, and 5.0, respectively. A similar set of four subgroups was identified in the patellofemoral joint, except that the fourth subgroup had limited meniscal lesions. The odds ratios of incident disease in the patellofemoral joint were 1.0, 3.8, 5.1, and 13.7, respectively. CONCLUSION: Different patterns of co-existing MRI lesions were identified that have different implications for risk of knee osteoarthritis. Meniscal damage seemed to play a different role in the development of incident disease in the tibiofemoral versus patellofemoral joints. This article is protected by copyright. All rights reserved.