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    Incidence of depression and anxiety in the spouses of patients with dementia: a naturalistic cohort study of recorded morbidity with a 6-year follow-up.

    Joling, Karlijn J; van Hout, Hein P J; Schellevis, Francois G; van der Horst, Henriette E; Scheltens, Philip; Knol, Dirk L; van Marwijk, Harm W J

    Am.J.Geriatr.Psychiatry. 2010;18(1545-7214 (Electronic)):146-153.

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    Abstract

    OBJECTIVE: Living with a demented person has been associated with high levels of clinical depression and anxiety. However, there are no prospective studies that allow good estimates of the incidence of depression and anxiety. In this study, the authors assess the long-term incidence of depression and anxiety in the spouses of patients with dementia as recorded by general practitioners. DESIGN: Prospective naturalistic cohort study with a comparison group. Data from medical records in 2001-2007 were analyzed. PARTICIPANTS: Two hundred eighteen spouses of patients with dementia and 353 age and gender-matched spouses of nondemented persons. SETTING: Seventy-one general practices in the Netherlands with a listed source population of 320,309 patients. MEASUREMENTS: Incidence rates (IRs) per 1,000 person-years and hazard ratios (HRs) of depression and anxiety; prescription rates (per 1,000 person-years) for antidepressants and anxiolytics. RESULTS: A new episode of depression was diagnosed in 18 spouses and 7 comparison spouses (IRs of 18.8/1,000 person-years and 4.4/1,000 person-years, respectively). Spouses of patients with dementia were far more likely to be diagnosed with depression than the comparison spouses (HR, 4.16; 95{\%} CI: 1.73-9.98). Spouses did not have a higher incidence of anxiety than the comparison group (HR, 1.26; 95{\%} CI: 0.58-2.71). The prescription rates for both antidepressants and anxiolytics were significantly higher for spouses than for the comparison group. CONCLUSION: The spouses of patients with dementia have a fourfold higher risk of a diagnosis of depression than the spouses of nondemented persons. The authors could not establish this for anxiety

    Bibliographic metadata

    Content type:
    Published date:
    Journal title:
    ISSN:
    Place of publication:
    Department of General Practice, Institute for Research in Extramural Medicine, VU University Medical Centre, Amsterdam, The Netherlands. k.joling@vumc.nl
    Volume:
    18
    Issue:
    1545-7214 (Electronic)
    Start page:
    146
    End page:
    153
    Total:
    8
    Pagination:
    146-153
    Digital Object Identifier:
    10.1097/JGP.0b013e3181bf9f0f
    Access state:
    Active

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    Record metadata

    Manchester eScholar ID:
    uk-ac-man-scw:280776
    Created by:
    Van Marwijk, Harm
    Created:
    1st December, 2015, 11:22:52
    Last modified by:
    Van Marwijk, Harm
    Last modified:
    1st December, 2015, 11:22:52

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