Related resources
Full-text held externally
- PMID: 23574726
- UKPMCID: 23574726
- DOI: 10.1088/1478-3975/10/3/036002
Search for item elsewhere
University researcher(s)
Academic department(s)
Modes of correlated angular motion in live cells across three distinct time scales.
Harrison, Andrew W; Kenwright, David A; Waigh, Thomas A; Woodman, Philip G; Allan, Victoria J
Physical biology. 2013;10(3):036002.
Access to files
Full-text and supplementary files are not available from Manchester eScholar. Full-text is available externally using the following links:
Full-text held externally
- PMID: 23574726
- UKPMCID: 23574726
- DOI: 10.1088/1478-3975/10/3/036002
Abstract
Particle tracking experiments with high speed digital microscopy yield the positions and trajectories of lipid droplets inside living cells. Angular correlation analysis shows that the lipid droplets have uncorrelated motion at short time scales (Ď„ < 1 ms) followed by anti-persistent motion for lag times in the range of 1 â©˝ Ď„ â©˝ 10 ms. The angular correlation at longer time scales, Ď„ > 10Â ms, becomes persistent, indicating directed movement. The motion at all time scales is associated with the lipid droplets being tethered to and driven along the microtubule network. The point at which the angular correlation changes from anti-persistent to persistent motion corresponds to the cross over between sub-diffusive and super diffusive motion, as observed by mean square displacement analysis. Correct analysis of the angular correlations of the detector noise is found to be crucial in modelling the observed phenomena.