Related resources
Full-text held externally
- DOI: 10.1186/s12891-016-0881-6
- PMID: 26774507
- UKPMCID: 26774507
Search for item elsewhere
University researcher(s)
Academic department(s)
Low vitamin D and the risk of developing chronic widespread pain: results from the European male ageing study.
McCabe, Paul S; Pye, Stephen R; Forti, Gianni; Giwercman, Aleksander; Huhtaniemi, Ilpo T; Kula, Krzysztof; Pendleton, Neil; Punab, Margus; Vanderschueren, Dirk; Wu, Frederick C; O'Neill, Terence W; McBeth, John; Lee, David M; Tajar, Abdelouahid; Bartfai, Gyorgy; Boonen, Steven; Bouillon, Roger; Casanueva, Felipe; Finn, Joseph D
BMC musculoskeletal disorders. 2016;17(1):32.
Access to files
Full-text and supplementary files are not available from Manchester eScholar. Full-text is available externally using the following links:
Full-text held externally
- DOI: 10.1186/s12891-016-0881-6
- PMID: 26774507
- UKPMCID: 26774507
Abstract
BACKGROUND: The association between low levels of vitamin D and the occurrence of chronic widespread pain (CWP) remains unclear. The aim of our analysis was to determine the relationship between low vitamin D levels and the risk of developing CWP in a population sample of middle age and elderly men. METHODS: Three thousand three hundred sixty nine men aged 40-79 were recruited from 8 European centres for a longitudinal study of male ageing, the European Male Ageing Study. At baseline participants underwent assessment of lifestyle, health factors, physical characteristics and gave a fasting blood sample. The occurrence of pain was assessed at baseline and follow up (a mean of 4.3 years later) by shading painful sites on a body manikin. The presence of CWP was determined using the ACR criteria for fibromyalgia. Serum 25-hydroxyvitamin D (25-(OH) D) was assessed by radioimmunoassay. Logistic regression was used to determine the relationship between baseline vitamin D levels and the new occurrence of CWP. RESULTS: Two thousand three hundred thirteen men, mean age 58.8 years (SD = 10.6), had complete pain and vitamin data available and contributed to this analysis. 151 (6.5 %) developed new CWP at follow up and 577 (24.9 %) were pain free at both time points, the comparator group. After adjustment for age and centre, physical performance and number of comorbidities, compared to those in upper quintile of 25-(OH) D ( ≥36.3 ng/mL), those in the lowest quintile (<15.6 ng/mL) were more likely to develop CWP (Odds Ratio [OR] = 1.93; 95 % CI = 1.0-3.6). Further adjustment for BMI (OR = 1.67; 95 % CI = 0.93-3.02) or depression (OR = 1.77; 95 % CI = 0.98-3.21), however rendered the association non-significant. CONCLUSIONS: Low vitamin D is linked with the new occurrence of CWP, although this may be explained by underlying adverse health factors, particularly obesity and depression.
Bibliographic metadata
- McCabe, Paul S
- Pye, Stephen R
- Forti, Gianni
- Giwercman, Aleksander
- Huhtaniemi, Ilpo T
- Kula, Krzysztof
- Pendleton, Neil
- Punab, Margus
- Vanderschueren, Dirk
- Wu, Frederick C
- O'Neill, Terence W
- McBeth, John
- Lee, David M
- Tajar, Abdelouahid
- Bartfai, Gyorgy
- Boonen, Steven
- Bouillon, Roger
- Casanueva, Felipe
- Finn, Joseph D