Related resources
Full-text held externally
- DOI: 10.3899/jrheum.080646
- PMID: 19012359
- UKPMCID: 19012359
Search for item elsewhere
University researcher(s)
Academic department(s)
Serum uric acid is associated with carotid plaques: the National Heart, Lung, and Blood Institute Family Heart Study.
Neogi, Tuhina; Ellison, R Curtis; Hunt, Steven; Terkeltaub, Robert; Felson, David T; Zhang, Yuqing
The Journal of rheumatology. 2009;36(2):378-84.
Access to files
Full-text and supplementary files are not available from Manchester eScholar. Full-text is available externally using the following links:
Full-text held externally
- DOI: 10.3899/jrheum.080646
- PMID: 19012359
- UKPMCID: 19012359
Abstract
OBJECTIVE: To examine the association of serum uric acid (SUA) with a marker of preclinical cardiovascular disease (CVD), carotid atherosclerotic plaques (PLQ), where early evidence of risk may be evident, focusing on individuals without CV risk factors. METHODS: The National Heart, Lung, and Blood Institute Family Heart Study is a multicenter study designed to assess risk factors for heart disease. PLQ were assessed with carotid ultrasound. We conducted sex-specific logistic regression to assess the association of SUA with presence of PLQ, including analyses among persons without risk factors related to both CVD and hyperuricemia. RESULTS: In total, 4,866 participants had both SUA and carotid ultrasound assessed (54% women, mean age 52 yrs, mean body mass index 27.6). The association of SUA with PLQ increased with increasing SUA levels, demonstrating a dose-response relation for men [OR 1.0, 1.29, 1.61, 1.75, for SUA categories < 5 (reference), 5 to < 6, 6 to < 6.8, >or= 6.8 mg/dl, respectively; p = 0.002]. Similar associations were found in men without CV risk factors. We found no relation of SUA with PLQ in women. CONCLUSION: In this large study, SUA was associated with carotid atherosclerotic plaques in men. Results were similar in the absence of CV risk factors. These results suggest that SUA may have a pathophysiologic role in atherosclerosis in men.