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Circadian clock genes contribute to the regulation of hair follicle cycling.

Lin, Kevin K; Kumar, Vivek; Geyfman, Mikhail; Chudova, Darya; Ihler, Alexander T; Smyth, Padhraic; Paus, Ralf; Takahashi, Joseph S; Andersen, Bogi

PLoS genetics. 2009;5(7):e1000573.

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Abstract

Hair follicles undergo recurrent cycling of controlled growth (anagen), regression (catagen), and relative quiescence (telogen) with a defined periodicity. Taking a genomics approach to study gene expression during synchronized mouse hair follicle cycling, we discovered that, in addition to circadian fluctuation, CLOCK-regulated genes are also modulated in phase with the hair growth cycle. During telogen and early anagen, circadian clock genes are prominently expressed in the secondary hair germ, which contains precursor cells for the growing follicle. Analysis of Clock and Bmal1 mutant mice reveals a delay in anagen progression, and the secondary hair germ cells show decreased levels of phosphorylated Rb and lack mitotic cells, suggesting that circadian clock genes regulate anagen progression via their effect on the cell cycle. Consistent with a block at the G1 phase of the cell cycle, we show a significant upregulation of p21 in Bmal1 mutant skin. While circadian clock mechanisms have been implicated in a variety of diurnal biological processes, our findings indicate that circadian clock genes may be utilized to modulate the progression of non-diurnal cyclic processes.

Bibliographic metadata

Content type:
Published date:
Language:
eng
Journal title:
Abbreviated journal title:
ISSN:
Place of publication:
United States
Volume:
5
Issue:
7
Pagination:
e1000573
Digital Object Identifier:
10.1371/journal.pgen.1000573
Pubmed Identifier:
19629164
Access state:
Active

Institutional metadata

University researcher(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:39242
Created by:
Paus, Ralf
Created:
8th October, 2009, 10:20:05
Last modified by:
Paus, Ralf
Last modified:
21st October, 2010, 10:55:18

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