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The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.

Bowman, S; Lawson, D; Basham, D; Brown, D; Chillingworth, T; Churcher, C M; Craig, A; Davies, R M; Devlin, K; Feltwell, T; Gentles, S; Gwilliam, R; Hamlin, N; Harris, D; Holroyd, S; Hornsby, T; Horrocks, P; Jagels, K; Jassal, B; Kyes, S; McLean, J; Moule, S; Mungall, K; Murphy, L; Oliver, K; Quail, M A; Rajandream, M A; Rutter, S; Skelton, J; Squares, R; Squares, S; Sulston, J E; Whitehead, S; Woodward, J R; Newbold, C; Barrell, B G

Nature. 1999;400(6744):532-8.

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Abstract

Analysis of Plasmodium falciparum chromosome 3, and comparison with chromosome 2, highlights novel features of chromosome organization and gene structure. The sub-telomeric regions of chromosome 3 show a conserved order of features, including repetitive DNA sequences, members of multigene families involved in pathogenesis and antigenic variation, a number of conserved pseudogenes, and several genes of unknown function. A putative centromere has been identified that has a core region of about 2 kilobases with an extremely high (adenine + thymidine) composition and arrays of tandem repeats. We have predicted 215 protein-coding genes and two transfer RNA genes in the 1,060,106-base-pair chromosome sequence. The predicted protein-coding genes can be divided into three main classes: 52.6% are not spliced, 45.1% have a large exon with short additional 5' or 3' exons, and 2.3% have a multiple exon structure more typical of higher eukaryotes.

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Content type:
Published date:
Language:
eng
Journal title:
Abbreviated journal title:
ISSN:
Place of publication:
ENGLAND
Volume:
400
Issue:
6744
Pagination:
532-8
Digital Object Identifier:
10.1038/22964
Pubmed Identifier:
10448855
Access state:
Active

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Record metadata

Manchester eScholar ID:
uk-ac-man-scw:67553
Created by:
Green, Linda
Created:
22nd October, 2009, 09:09:35
Last modified by:
Green, Linda
Last modified:
12th November, 2012, 20:09:30

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