Related resources
Full-text held externally
- PMID: 10448855
- UKPMCID: 10448855
- DOI: 10.1038/22964
Search for item elsewhere
University researcher(s)
Academic department(s)
The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.
Bowman, S; Lawson, D; Basham, D; Brown, D; Chillingworth, T; Churcher, C M; Craig, A; Davies, R M; Devlin, K; Feltwell, T; Gentles, S; Gwilliam, R; Hamlin, N; Harris, D; Holroyd, S; Hornsby, T; Horrocks, P; Jagels, K; Jassal, B; Kyes, S; McLean, J; Moule, S; Mungall, K; Murphy, L; Oliver, K; Quail, M A; Rajandream, M A; Rutter, S; Skelton, J; Squares, R; Squares, S; Sulston, J E; Whitehead, S; Woodward, J R; Newbold, C; Barrell, B G
Nature. 1999;400(6744):532-8.
Access to files
Full-text and supplementary files are not available from Manchester eScholar. Full-text is available externally using the following links:
Full-text held externally
- PMID: 10448855
- UKPMCID: 10448855
- DOI: 10.1038/22964
Abstract
Analysis of Plasmodium falciparum chromosome 3, and comparison with chromosome 2, highlights novel features of chromosome organization and gene structure. The sub-telomeric regions of chromosome 3 show a conserved order of features, including repetitive DNA sequences, members of multigene families involved in pathogenesis and antigenic variation, a number of conserved pseudogenes, and several genes of unknown function. A putative centromere has been identified that has a core region of about 2 kilobases with an extremely high (adenine + thymidine) composition and arrays of tandem repeats. We have predicted 215 protein-coding genes and two transfer RNA genes in the 1,060,106-base-pair chromosome sequence. The predicted protein-coding genes can be divided into three main classes: 52.6% are not spliced, 45.1% have a large exon with short additional 5' or 3' exons, and 2.3% have a multiple exon structure more typical of higher eukaryotes.
Bibliographic metadata
- Bowman, S
- Lawson, D
- Basham, D
- Brown, D
- Chillingworth, T
- Churcher, C M
- Craig, A
- Davies, R M
- Devlin, K
- Feltwell, T
- Gentles, S
- Gwilliam, R
- Hamlin, N
- Harris, D
- Holroyd, S
- Hornsby, T
- Horrocks, P
- Jagels, K
- Jassal, B
- Kyes, S
- McLean, J
- Moule, S
- Mungall, K
- Murphy, L
- Oliver, K
- Quail, M A
- Rajandream, M A
- Rutter, S
- Skelton, J
- Squares, R
- Squares, S
- Sulston, J E
- Whitehead, S
- Woodward, J R
- Newbold, C
- Barrell, B G