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Making the right connections: biological networks in the light of evolution

Knight, C.G. and J.W. Pinney

Bioessays. 2009;31(10):1080-1090.

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Abstract

Our understanding of how evolution acts on biological networks remains patchy, as is our knowledge of how that action is best identified, modelled and understood. Starting with network structure and the evolution of protein-protein interaction networks, we briefly survey the ways in which network evolution is being addressed in the fields of systems biology, development and ecology. The approaches highlighted demonstrate a movement away from a focus on network topology towards a more integrated view, placing biological properties centre-stage. We argue that there remains great potential in a closer synergy between evolutionary biology and biological network analysis, although that may require the development of novel approaches and even different analogies for biological networks themselves.

Bibliographic metadata

Type of resource:
Content type:
Publication type:
Publication form:
Published date:
Journal title:
ISSN:
Volume:
31
Issue:
10
Start page:
1080
End page:
1090
Total:
11
Pagination:
1080-1090
Digital Object Identifier:
10.1002/bies.200900043
Access state:
Active

Institutional metadata

University researcher(s):
Academic department(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:7074
Created by:
Knight, Christopher
Created:
21st September, 2009, 15:27:33
Last modified by:
Knight, Christopher
Last modified:
6th January, 2015, 08:06:44

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