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- DOI: 10.3899/jrheum.090113
- PMID: 19833751
- UKPMCID: 19833751
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Perturbed insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 are not associated with chronic widespread pain in men: results from the European Male Ageing Study.
McBeth, John; Tajar, Abdelouahid; O'Neill, Terence W; Macfarlane, Gary J; Pye, Stephen R; Bartfai, Gyorgy; Boonen, Steven; Bouillon, Roger; Casanueva, Felipe; Finn, Joseph D; Forti, Gianni; Giwercman, Aleksander; Han, Thang S; Huhtaniemi, Ilpo T; Kula, Krzysztof; Lean, Michael E J; Pendleton, Neil; Punab, Margus; Silman, Alan J; Vanderschueren, Dirk; Wu, Frederick C W
The Journal of rheumatology. 2009;36(11):2523-30.
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Full-text held externally
- DOI: 10.3899/jrheum.090113
- PMID: 19833751
- UKPMCID: 19833751
Abstract
OBJECTIVE: To determine whether perturbations of insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 (IGFBP-3) were associated with the presence of chronic widespread pain (CWP) in men. METHODS: The European Male Ageing Study (EMAS) is an 8-center population-based study of men aged 40-79 years recruited from population registers. A questionnaire asked about the presence and duration of musculoskeletal pain, from which subjects reporting CWP were identified. Subjects also had an interviewer-assisted questionnaire: levels of physical activity and mood were assessed, and height and weight were measured. IGF-1 and IGFBP-3 were assayed from a fasting blood sample. Logistic regression models were used to determine the association between IGF measures and CWP. Results were expressed as odds ratios or relative risk ratios. RESULTS: A total of 3206 subjects provided full data. Of those, 1314 (39.0%) reported no pain in the past month and 278 (8.3%) reported pain that satisfied criteria for CWP. IGF-1 concentrations were similar among subjects who reported no pain and those with CWP: 131.5 mg/l and 128.4 mg/l, respectively. This was true also for IGFBP-3 (4.3 and 4.3 mg/l). Obesity was associated with low IGF-1 and a high IGFBP-3/IGF-1 ratio, indicating less bioavailable IGF-1, irrespective of pain status. This relationship persisted after adjustment for comorbidities, depression, smoking, alcohol consumption, and quality of life. CONCLUSION: Overall CWP was not associated with perturbations in IGF-1 and IGFBP-3 concentrations. Hypofunctioning of the axis was noted among subjects who were obese and this was not specific to CWP. These data suggest that IGF-1 is unlikely to be etiologically important in relation to CWP, although the relationship with growth hormone remains to be elucidated.
Bibliographic metadata
- McBeth, John
- Tajar, Abdelouahid
- O'Neill, Terence W
- Macfarlane, Gary J
- Pye, Stephen R
- Bartfai, Gyorgy
- Boonen, Steven
- Bouillon, Roger
- Casanueva, Felipe
- Finn, Joseph D
- Forti, Gianni
- Giwercman, Aleksander
- Han, Thang S
- Huhtaniemi, Ilpo T
- Kula, Krzysztof
- Lean, Michael E J
- Pendleton, Neil
- Punab, Margus
- Silman, Alan J
- Vanderschueren, Dirk
- Wu, Frederick C W
- Forti, Gianni
- Petrone, Luisa
- Cilotti, Antonio
- Vanderschueren, Dirk
- Boonen, Steven
- Borghs, Herman
- Kula, Krzysztof
- Slowikowska-Hilczer, Jolanta
- Walczak-Jedrzejowska, Renata
- Huhtaniemi, Ilpo
- Giwercman, Aleksander
- Wu, Frederick
- Silman, Alan
- O'Neill, Terence
- Finn, Joseph
- Steer, Philip
- Tajar, Abdelouahid
- Lee, David
- Pye, Stephen
- Casanueva, Felipe
- Ocampo, Marta
- Lage, Mary
- Bartfai, Gyorgy
- F??ldesi, Imre
- Fejes, Imre
- Punab, Margus
- Korrovitz, Paul
- Jiang, Min