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A rapid and transient peripheral inflammatory response precedes brain inflammation after experimental stroke.

Chapman, Katie Z; Dale, Verity Q; Dénes, Adám; Bennett, Gavin; Rothwell, Nancy J; Allan, Stuart M; McColl, Barry W

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2009;29(11):1764-8.

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Abstract

Increasing evidence suggests that peripheral inflammatory responses to stroke and other brain injuries have an important role in determining neurological outcome. The mediators of this response and the temporal relationships between peripheral and central inflammatory alterations are poorly understood. In this study, we show that experimental stroke in mice induces a peripheral inflammatory response that peaks 4 h after stroke, and precedes the peak in brain inflammation 24 h after stroke. This peripheral response is dominated by the induction of the chemokine CXCL-1 and the proinflammatory cytokine interleukin-6 and could serve as an accessible target for therapy and as a source of biomarkers predictive of prognosis.

Bibliographic metadata

Content type:
Published date:
Language:
eng
Abbreviated journal title:
ISSN:
Place of publication:
United States
Volume:
29
Issue:
11
Pagination:
1764-8
Digital Object Identifier:
10.1038/jcbfm.2009.113
Pubmed Identifier:
19654587
Pii Identifier:
jcbfm2009113
Access state:
Active

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University researcher(s):
Academic department(s):

Record metadata

Manchester eScholar ID:
uk-ac-man-scw:76672
Created by:
Rothwell, Nancy
Created:
11th February, 2010, 11:43:42
Last modified by:
Rothwell, Nancy
Last modified:
7th February, 2011, 20:08:09

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