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- DOI: 10.1530/EJE-09-0970
- PMID: 20231367
- UKPMCID: 20231367
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Endogenous hormones, androgen receptor CAG repeat length and fluid cognition in middle-aged and older men: results from the European Male Ageing Study (EMAS).
Lee, David; Ulubaev, Aslan; Tajar, Abdelouahid; Pye, Stephen; Pendleton, Neil; Purandare, Nitin; O'Neill, Terence; O'Connor, Daryl; Labrie, Fernand; Platt, Hazel; Payne, Debbie; Bartfai, Gyorgy; Boonen, Steven; Casanueva, Felipe; Finn, Joseph; Forti, Gianni; Giwercman, Aleksander; Han, Thang; Huhtaniemi, Ilpo; Kula, Krzysztof; Lean, Michael; Punab, Margus; Silman, Alan; Vanderschueren, Dirk; Wu, Fredrick; EMAS_Study_Group
European journal of endocrinology / European Federation of Endocrine Societies. 2010;162(6):1155-1164.
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Full-text held externally
- DOI: 10.1530/EJE-09-0970
- PMID: 20231367
- UKPMCID: 20231367
Abstract
Objective: Data remain divergent regarding the activational effects of endogenous hormones on adult cognitive function. We examined the association between cognition, hormones and androgen receptor (AR) CAG repeat length in a large cohort of men. Design: Community-based, cross-sectional study of 3,369 men aged 40-79 years. Methods: Cognition tests were the Rey-Osterrieth Complex Figure, Camden Topographical-Recognition-Memory and Digit-Symbol Substitution. A fluid cognition (FC) z-score was computed from the individual tests. Testosterone (T), oestradiol (E2) and 5alpha-dihydrotestosterone (DHT) were measured by gas chromatography-mass spectrometry (GC-MS); dehydroepiandrosterone-sulphate (DHEAS), luteinising hormone (LH), follicle-stimulating hormone (FSH) and sex hormone-binding globulin (SHBG) by electrochemiluminescence. Free T/E2 were calculated from total hormone, SHBG and albumin. CAG repeat lengths were assayed by PCR genotyping. Results: Total and free T were associated with higher, LH and FSH with lower FC z-scores in age-adjusted linear regressions. After adjusting for health, lifestyle and centre, a modest association was only observed between DHEAS and a lower FC z-score (beta=-0.011, P=0.02), although this was driven by subjects with DHEAS levels >10micromol/L. Locally-weighted plots revealed no threshold effects between hormones and fluid cognition. There was no association between CAG repeat length and FC z-score after adjustment for age and centre (beta=-0.007, P=0.06), nor any interaction effect between CAG repeat length and hormones. Conclusion: Our results suggest endogenous hormones are not associated with a vision-based measure of fluid cognition among healthy, community-dwelling men. Further studies are warranted to determine whether 'high' DHEAS levels are associated with poorer performance on a broader range of neuropsychological tests.
Bibliographic metadata
- Lee, David
- Ulubaev, Aslan
- Tajar, Abdelouahid
- Pye, Stephen
- Pendleton, Neil
- Purandare, Nitin
- O'Neill, Terence
- O'Connor, Daryl
- Labrie, Fernand
- Platt, Hazel
- Payne, Debbie
- Bartfai, Gyorgy
- Boonen, Steven
- Casanueva, Felipe
- Finn, Joseph
- Forti, Gianni
- Giwercman, Aleksander
- Han, Thang
- Huhtaniemi, Ilpo
- Kula, Krzysztof
- Lean, Michael
- Punab, Margus
- Silman, Alan
- Vanderschueren, Dirk
- Wu, Fredrick
- EMAS_Study_Group